In vitro antifungal synergism between pyrrolnitrin and clotrimazole.
نویسندگان
چکیده
منابع مشابه
In vitro antifungal activity of clotrimazole (Bay b 5097).
The in vitro antifungal activity of clotrimazole (Bay b 5097) was compared with those of amphotericin B, griseofulvin, nystatin, and pyrrolnitrin. The inhibitory activity of clotrimazole against most systemic pathogens was comparable to that of amphotericin B; minimal inhibitory concentrations of the two drugs for Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococ...
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The lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. Unfortunately, a large number of Candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. The aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...
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Clotrimazole, an imidazole derivative antifungal agent is widely used for the treatment of mycotic infections of the genitourinary tract. In order to develop alternative formulation for the vaginal administration of clotrimazole to provide sustained and controlled release of appropriate drug for local vaginal therapy, liposomes/niosomes were evaluated as delivery vehicles. To optimize the prepa...
متن کاملMechanism of action of the antifungal antibiotic pyrrolnitrin.
Pyrrolnitrin at 10 mug/ml inhibited the growth of Saccharomyces cerevisiae, Penicillium atrovenetum, and P. oxalicum. The primary site of action of pyrrolnitrin on S. cerevisiae was the terminal electron transport system between succinate or reduced nicotinamide adenine dinucleotide (NADH) and coenzyme Q. At growth inhibitory concentrations, pyrrolnitrin inhibited endogenous and exogenous respi...
متن کاملIn vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi
BACKGROUND To investigate whether chloroquine enhances the effect of antibiotics against Orientia tsutsugamushi, the causative organism of scrub typhus, we compared the effect of antibiotics in combination with chloroquine with the effect of antibiotics alone in vitro. MATERIALS AND METHODS The Boryong or AFSC-4 strain was inoculated into ECV304 cells, and incubated in medium containing doxyc...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Mycology
سال: 1989
ISSN: 1884-6971,0583-0516
DOI: 10.3314/jjmm1960.30.202